Antihistamine Brands

There are many different antihistamine brands available and sorting through them can be confusing. How do you know which one will work for you? In an effort to make your decision a little easier, we have listed some of the most commonly-used antihistamine brands along with important information that is specific to each.

Of course, your doctor should assist you in deciding which one will be ideal for your needs. Under each antihistamine brand heading, you will find information on whether the medicine is a prescription or can be purchased over the counter, alternative names and available generic versions, as well as in what form this particular antihistamine is available. Basic background information on the antihistamine brands is given as well, along with what problems or areas they specifically target.

When sorting through antihistamine brands, it is important to consider any current medications you may be taking. Certain medicines, over the counter or prescription, can interfere with your antihistamine, causing a decrease in both its effectiveness and may even interact to cause a more serious health problem. In rare cases, a few antihistamine brands interact negatively with certain food or beverages. Some antihistamine brands contain sedatives and are intended for nighttime relief while others are formulated to be non-drowsy. Such differences in antihistamine brands can have a negative impact if taken wrongly or mistakenly. Taking just a few minutes to research the available options can alleviate your symptoms faster and can save you a lot of trouble later.

The list below details some of the available antihistamine options.


Formerly available by prescription only, Allegra is now available over the counter at a reasonable price. Allegra is a brand name for fexofenadine. According to, fexofenadine is one of a class of medications called “second generation antihistamines” or histamine receptor antagonists. Click here to read more about Allegra Antihistamine.

Benadryl Allergy

Benadryl Allergy is used to treat a variety of symptoms associated with allergies, as well as hay fever, upper respiratory infections and the common cold. This medicine has proven effective against watery eyes, rashes, sneezing, runny noses, coughing and itchiness in the eyes, nose or throat. Click here to learn more about Benadryl Allergy.


Promethazine is also used in the ingredients of other prescription drugs to battle severe allergic reactions. It can also be used to sedate patients before surgery and prevent nausea afterwards. Promethazine can do this by blocking and changing the direction of a unique chemical in the brain. Click here to learn more about Promethazine.


Tussionex works to reduce these symptoms. The two active ingredients are chlorpheniramine and hydrocodone.  Click here to learn more about Tussionex.

Tylenol Allergy

Tylenol Allergy is an over-the-counter medication that combines the powerful pain relief of Tylenol with potent allergy medications to create a medicine that will fight the most painful allergy symptoms including headache, sinus congestion, nasal congestion, sinus pressure, runny nose, sneezing, aches and pains, itching nose or throat, and itchy watery eyes. Click here to learn more about Tylenol Allergy.

Dimetane Cough Syrup

Although Dimetane Cough Syrup comes in liquid form, it has not been proven safe for children under six years old to take. This rule applies to all cough and cold products. Click here to read more about Dimetane Cough Syrup.

Promethazine Phenergan Antihistamine

Promethazine (Phenergan) Antihistamine is effective for treatment of allergies. It also is used to prevent motion sickness and in surgery applications. Phenergan is one of the brand names for distribution of Promethazine, which is the generic form of the antihistamine.

Loratadine Alavert Claritin Antihistamine

Loratadine, more commonly known under the brand name Claritin, is a non-prescription antihistamine medication that is approved for the treatment of allergies in both children and adults. Loratadin

Loratadine Claritin Antihistamine

Loratadine is the active ingredient in Claritin and it comes in a few forms that are all taken orally. Claritin comes in tablets, syrup, and dissolving tablets. The tablets are simply taken as directed and the syrup is to be measured and taken as a drink.

Doxylamine : Vicks NyQuil : Alka-Seltzer Plus Antihistamine

Doxylamine is an antihistamine found in many nighttime medications which acts as a sedative. Medicines that include the antihistamine doxylamine not only ease the symptoms of allergies and colds, but also encourage restorative sleep. Doxylamine is usually found in nighttime versions of traditional antihistamine medications.

Dimenhydrinate Dramamine Antihistamine

The antihistamine Dimenhydrinate is most commonly known in the United States under the brand name Dramamine. This antihistamine comes most commonly in pill form, though both liquid and suppository versions of the antihistamine also exist.

Clemastine Tavist Antihistamine

As an antihistamine, Clemastine works by blocking the action of histamine, a substance found in the body which causes allergic symptoms (such as fits of sneezing, watery or runny nasal passages, and irritation of the eyes).

Chlorpheniramine Chlor-Trimeton Antihistamine

Chlorpheniramine (KLOOR fen EAR a mean), also known as Chlorpheniramine Maleate, is the active ingredient in several antihistamine medications and is marketed under many different names or brands.

Cetirizine Zyrtec Antihistamine

The brand-name antihistamine Zyrtec is manufactured by McNeil Consumer Healthcare and distributed by Pfizer Pharmaceutical Corporation. Zyrtec was initially a prescription-only antihistamine; however, in 2007 its status was changed to a non-prescription drug.

Brompheniramine Dimetapp Antihistamine

Dimetapp Cold and Allergy Elixir serves as an anti inflammatory, antihistamine, cold remedy. Dimetapp’s antihistamine properties help relieve symptoms commonly caused by seasonal allergies. Because an antihistamine is also an anti-inflammatory, and because Dimetapp contains a nasal decongestant, Dimetapp also works as a remedy for the common cold.

Astemizole Hismanal Antihistamine

Like most antihistamine drugs, Astemizole acts by binding with the cell’s histamine receptor sites, thereby blocking the ability of the cell to take in histamines. Astemizole specifically targets the H1 receptor sites of many of the body’s organs, including the stomach, intestines and uterus.