Non-sedating antihistamines are helping to improve the lives of countless people who suffer from the symptoms of serious allergic reactions. Although antihistamines are by no means a recent discovery, the development of the new class of non-sedating antihistamines allows many more allergy sufferers to benefit from the therapeutic effects of the drugs without experiencing their annoying and often unmanageable side effects such as sedation, which is a condition or state in which one feels overly calm and serene; it is akin to being tranquillized. For years, the cost of relief for these people was feeling groggy and out of sorts for hours. With non-sedating antihistamines, it is no longer necessary to choose between being free from allergy symptoms and going about your daily business; it is possible to do both.
Histamine is a naturally occurring nitrogen-based chemical that is essential to localized immune responses and various physiological bodily functions, including sleep, sexual activity and much more. The secretion of histamine is stimulated by a wide array of foreign pathogens--think reaction causing stimuli that are transmitted by such things as insect bites, plant pollen, pet dander and many others. It is the release of histamine that causes the body to protect itself from the pathogens in ways that we recognize as an allergic reaction. Histamine is responsible for the immune response to the stimuli that we are familiar in symptoms as itching, sneezing, hives, runny nose and watery eyes. Non-sedating histamine targets these symptoms.
The Difference Between Traditional and Non-Sedating Antihistamines
Traditional antihistamines act by minimizing swelling and controlling the dilation of small blood vessels that translate to those common allergy symptoms. They accomplished this by blocking the histamine from connecting with its receptors in specific nerve, muscle and glandular types of cells. There are some others as well that play a less significant role. Non-sedating antihistamines are as effective as others but offer additional benefits. The most significant advantage of non-sedating antihistamines is just what their mane implies: they do not have a sedative-like effect on the user. There are many very effective non-sedating antihistamines on the market today, including the well-known brands Allegra, Zyrtec, Claritin, Ceterizine, Loratadine and more.
The mechanism by which non-sedating antihistamines work effectively without causing sedation is remarkably simple. Unlike regular antihistamines, non-sedating antihistamines do not activate the nerve cell receptors allowing them to generate the undesired response; they bind to them instead. In effect, this prevents them from acting as they would normally and releasing the histamine. Because the new class of non-sedating antihistamines is far more accurate than its predecessors in terms of targeting specific nerve cell receptors, there is a much lower incidence of non-sedating antihistamines binding to inappropriate cells, such as certain ones in the brain that are responsible for causing sedation when activated. Non-sedating antihistamines actually have the capacity to avoid them. Today, even the most serious allergic reactions can be controlled effectively with non-sedating antihistamines without the risk of sedation.