Tussionex is an antihistamine used to provide relief from symptoms of the common cold or flu, including runny or stuffy noses, sneezing and coughing.

Histamine is a naturally occurring chemical in the body, and when too much is produced, it can cause sneezing, runny nose, and itchy, watery eyes.

Tussionex works to reduce these symptoms. The two active ingredients are chlorpheniramine and hydrocodone. Chlorpheniramine reduces the amount of histamine in the body, providing relief from cold and allergy symptoms, and hydrocodone is a cough suppressant.

The generic brand for Tussionex is chlorpheniramine and hydrocodone. It is also found under the brand names: Tussionex PennKinetic, TussiCaps, S-T Forte 2, Novasus, and HyTan.

Prescription Tussionex

Tussionex is a prescription antihistamine and should be taken exactly as prescribed by your doctor. Hydrocodone, an active ingredient, can be addicting, so it is important to take this medicine only as long as it is prescribed and at the correct dosage.

Overdose Information

If you have overdosed on this medication, it is imperative to seek emergency help immediately. Overdosing on Tussionex can be fatal, especially for children.

Some overdose symptoms include: light-headedness, fainting, dilated pupils, nausea, vomiting, dry mouth, clammy and cold skin, slow heart rate, flushed skin, blue colored skin, extreme drowsiness, dizziness, seizures or convulsions, and shallow breathing.


Tussionex may cause some people to experience impaired thinking and reactions so caution should be used when driving or doing anything requiring alertness. Alcohol should be avoided while taking Tussionex.

Some general side effects include: dizziness, drowsiness, trouble concentrating, mood changes, anxiety, blurred vision, constipation, nausea, loss of appetite, vomiting, dry mouth or throat, sweating, mild itching or skin rash.

Serious side effects that should be immediately reported to your doctor include: weak or shallow breathing, chest tightness, painful urination, urinating less than usual or not at all, confusion, hallucinations, or other unusual behavior.

Signs of an allergic reaction are: swelling of the face, lips, tongue, or throat, difficulty breathing, or hives. If any of these symptoms develop, seek emergency help at once.

Contact your doctor if you experience any other side effects not listed here.

Drug Interactions

Before taking Tussionex, inform your doctor of any medications you are currently taking, prescription and over-the-counter, as some are known to cause interactions.

Other allergy medications, sleeping aids, narcotics, muscle relaxers, and depression, anxiety, and seizure medications may increase sleepiness when combined with Tussionex.

Some of the drugs that are known to interact with Tussionex are: atropine, benztropine, dimenhydrinate, methscopolamine, scopolamine, bronchodilators, glycopyrrolate, mepenzolate, bladder and urinary medications, irritable bowel medications, and MAO inhibitors.

This is not a complete list of medications and there may be others that interact with Tussionex. Be sure to tell your doctor of any medicines you take, including vitamins, herbal supplements, and minerals.

Use during Pregnancy

Tussionex is only recommended for pregnant women if there are no other alternative medications available, so discuss the risks versus benefits of taking Tussionex if you are pregnant, think you are pregnant, or breastfeeding.

Reference: http://www.drugs.com/tussionex.html